A precursor of phospholipids in the treatment of severe traumatic comas

Cohadon F, Richer E, Poletto B.

Neurochirurgie 1982;28(4):287-90


CDP Choline, a metabolic precursor of phospholipids, has been tested against placebo in a controlled randomized double blind study concerning 60 cases of severe head injuries (wide-spread cerebral contusions and/or severe concussion).  In the treated group, a shortening of the comatose period and an acceleration of neurological deficits recovery have been observed. These results are tentatively attributed to an effect of CDP Choline against brain edema, already documented on experimental models.

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