CDP-Choline In Glaucoma
Pharmacodynamics of citicoline (CDP-choline) relevant to the treatment of glaucoma.

Grieb P, Rejdak R

Laboratory of Experimental Pharmacology, 
Medical Research Center, 
Polish Academy of Sciences, Warsaw, Poland.
J Neurosci Res 2002 Jan 15;67(2):143-8


Citicoline (CDP-choline) is a nontoxic and well-tolerated drug used in pharmacotherapy of brain insufficiency and some other neurological disorders, such as stroke, brain trauma, and Parkinson's disease. A few reports indicate that CDP-choline treatment may also be beneficial in glaucoma.  Currently glaucoma is considered a neurodegenerative disease in which retinal ganglion cells (RGC) slowly die, likely in the apoptotic mechanism. CDP-choline is a natural precursor of cellular synthesis of phospholipids, mainly phosphatydylcholine.  Enhancement of Phosphatidylcholine synthesis may counteract neuronal apoptosis and provide neuroprotection. CDP-choline, when administered, undergoes a quick transformation to cytidine and choline, which are believed to enter brain cells separately and provide neuroprotection by enhancing Phosphatidylcholine synthesis; similar effect may be expected to occur in glaucomatous RGC.  Furthermore, CDP-choline stimulates some brain neurotransmitter systems, including the dopaminergic system, and dopamine is known as a major neurotransmitter in retina and postretinal visual pathways.  In a double-blind, placebo-controlled study, treatment of glaucoma resulted in functional improvement in the visual system noted with electrophysiological methods.  Development of CDP-choline as a treatment for glaucoma is indicated.

 | Home | Order |

 1.   CDP choline  may be useful in the treatment of Alzheimer's
 2.   CDP choline  therapeutic effects in Alzheimer's
 3.   CDP choline  choline  effects on cognition in patients with Alzheimer's
 4.   CDP choline  significant improvement in Alzheimer's after 1 month  
 5.   CDP choline  improved mental performance in Alzheimer's
 6.   CDP choline  improvement in glaucoma
 7.   CDP choline  therapeutic value in the treatment of glaucoma
 8.   CDP choline  improved retinal responses in patients with glaucoma
 9.   CDP choline  in acute ischemic stroke
10.  CDP choline  randomized trial in acute ischemic stroke
11.  CDP choline  treatment after traumatic brain injury
12.  CDP choline  action and effects in ischemic brain injury